Which condition is most likely to impair mobility in the legs?

Paraplegia is a condition characterized by the loss of movement and sensation in the lower half of the body, typically affecting the legs. This impairment is usually due to spinal cord injuries or diseases that damage the nervous system at the thoracic, lumbar, or sacral levels, leading to partial or total loss of function in the legs.

Individuals with paraplegia may face significant challenges in mobility, often requiring the use of wheelchairs, assistive devices, or other forms of support to move. The degree of impairment can vary depending on the severity of the injury or condition causing the paraplegia.

Other conditions listed, such as paresis, which is a weakness of voluntary movement rather than complete loss, don’t usually result in the same degree of mobility impairment as paraplegia. Parasite infections and pathogens could affect the body in various ways, including fatigue or weakness, but they do not specifically target the mobility of the legs like paraplegia does. Thus, paraplegia is the most direct and severe condition that would impair leg mobility.