Which of the following is a symptom that can be aggravated over time in chronic diseases?

Exacerbation is the correct choice because it refers to a period during which symptoms of a chronic disease become more severe or are aggravated. In chronic diseases, patients may experience fluctuations in their condition, where symptoms can become worse due to various factors such as stress, infections, or other underlying health issues. This cyclical pattern is a hallmark of chronic illnesses, and understanding exacerbation is crucial in managing these conditions effectively.

The other terms do not reflect the concept of worsening symptoms over time. Remission describes a phase where disease symptoms are reduced or not present, recovery refers to the process of returning to health from an illness, and prognosis relates to the expected outcome of a disease rather than a fluctuation in symptoms.